Diabetic neuropathy is nerve damage that manifests in individuals with diabetes. There are different types of diabetic neuropathy, such as: symmetric polyneuropathy, autonomic neuropathy, and motor neuropathies. Diabetic neuropathy commonly affects the feet and legs, but can also affect the hands and arms. Symptoms include numbness, tingling, pain, loss of sensation and muscle weakness, as well as problems with the digestive system, urinary tract, blood vessels and heart. In severe cases, it can lead to foot ulcers and infections, necessitating amputations. The cause of diabetic neuropathy is thought to be related to downstream metabolic and vascular effects of having chronically high blood sugar.