Refractory headaches tend to occur frequently, usually on a daily basis and do not respond well to standard treatments. They may include a variety of headaches, such as migraines, tension-type headaches, and cluster headaches. Symptoms include moderate to severe pain, sensitivity to light and sound, and nausea. Refractory headaches can be caused by a variety of factors, including excessive medication use, underlying medical conditions, and psychological factors. It is important to know that not all refractory headaches have a definite cause and that a combination of factors can be responsible. For this reason, an appropriate diagnosis and treatment plan is needed to address the cause of the headache.